Tbx18 and the generation of a biological pacemaker. Are we there yet?

A group of approximately 10,000 cells in the sinoatrial node (SAN), which is located at the entry of the right superior caval vein into the right atrium, is responsible for regular heart beating under different physiological conditions [1]. While the SAN is reliably working for most of our life, in the elderly, sick sinus syndrome (SSS), or sinus node dysfunction (SND) is prevalent [2] and responsible for 30 to 50% of all electronic pacemaker implantations [3]. Moreover, SSS is also often associated with the development of atrial fibrillation [4]

Approximate expression for the dynamic structure factor in the Lieb-Liniger model

Recently, Imambekov and Glazman [Phys. Rev. Lett. 100, 206805 (2008)] showed that the dynamic structure factor (DSF) of the 1D Bose gas demonstrates power-law behaviour along the limiting dispersion curve of the collective modes and calculated the corresponding exponents exactly. Combining these recent results with a previously obtained strong-coupling expansion we present an interpolation formula for the DSF of the 1D Bose gas. The obtained expression is further consistent with exact low energy exponents from Luttinger liquid theory and shows nice agreement with recent numerical results.Comment: 4 pages, 3 figure

Perinatale programmering van volwassen seksueel gedrag en partner preferentie van de rat

Aims of the present study 1. Is adulttestosterone-induced mounting behavior of female rats organized by perinatally circulating testosterone (T)? 2. What role does the prenatal position in utero relative to a brother play in this respect? 3. Is adult partner preference behavior of female rats organized by perinatal T? 4. Is adult partner preference behavior of male rats organized by perinatal T, D HT or E2? 5. What effects do 8-0H-DPAT and yohimbine (well known rat "aphrodisiacs") have on partner preference and sexual behavior in the male rat?In dit proefschrift is geprobeerd antwoorden te vinden op de volgende vragen: 1 Is volwassen door testosteron-geinduceerd beklimgedrag van vrouwelijke ratten op enigerlei wijze geprogrammeerd door perinataai circulerend testosteron (T)? 2 Speelt de prenatale ligging ten opzichte van broertjes hierbij een rol? 3 Wordt de volwassen partner preferentie van vrouwelijke ratten geprogrammeerd door perinataai aanwezig T? 4 Wordt de volwassen partner preferentie van mannelijke ratten geprograrnmeerd door perinataai Ten/of de dihydrotestosteron (DHT) en oestradiol (Ez)? 5 Welke effecten hebben 8-0H-DPAT en yohimbine (bekende ratte-"aphrodisiaca") op partner preferentie en seksueel gedrag van mannelelijke ratten

Unified powered flight guidance

A complete revision of the orbiter powered flight guidance scheme is presented. A unified approach to powered flight guidance was taken to accommodate all phases of exo-atmospheric orbiter powered flight, from ascent through deorbit. The guidance scheme was changed from the previous modified version of the Lambert Aim Point Maneuver Mode used in Apollo to one that employs linear tangent guidance concepts. This document replaces the previous ascent phase equation document

Evolving a DSL implementation

Domain Specific Languages (DSLs) are small languages designed for use in a specific domain. DSLs typically evolve quite radically throughout their lifetime, but current DSL implementation approaches are often clumsy in the face of such evolution. In this paper I present a case study of an DSL evolving in its syntax, semantics, and robustness, implemented in the Converge language. This shows how real-world DSL implementations can evolve along with changing requirements

Canadian Highly Erodible Land Planner (CanHELP 3.0)

Non-Peer Reviewe

The role of POPDC proteins in cardiac pacemaking and conduction

The Popeye domain-containing (POPDC) gene family, consisting of Popdc1 (also known as Bves), Popdc2, and Popdc3, encodes transmembrane proteins abundantly expressed in striated muscle. POPDC proteins have recently been identified as cAMP effector proteins and have been proposed to be part of the protein network involved in cAMP signaling. However, their exact biochemical activity is presently poorly understood. Loss-of-function mutations in animal models causes abnormalities in skeletal muscle regeneration, conduction, and heart rate adaptation after stress. Likewise, patients carrying missense or nonsense mutations in POPDC genes have been associated with cardiac arrhythmias and limb-girdle muscular dystrophy. In this review, we introduce the POPDC protein family, and describe their structure function, and role in cAMP signaling. Furthermore, the pathological phenotypes observed in zebrafish and mouse models and the clinical and molecular pathologies in patients carrying POPDC mutations are described

Special issue: left-right asymmetry and cardiac morphogenesis

n/